abstract：:POZ/BTB proteins influence cellular development and in some examples act as oncoproteins. However, several POZ/BTB transcription factors have been found in terminally differentiated neurons, where their functions remain unknown. One example is NAC1, a constitutively-expressed protein that can regulate behaviors associ...

journal_title：Neuroscience research

authors： Korutla L,Neustadter JH,Fournier KM,Mackler SA

更新日期：2003-05-01 00:00:00

abstract：:Deficiency in n-3 fatty acids is known to disturb the release of dopaminergic neurotransmitters in rat brain. Since isomerization reduces the bioavailability of dietary fatty acids, the effect of the conversion of alpha-linolenic acid into trans alpha-linolenic acid on the dopaminergic neurotransmission was studied. R...

journal_title：Neuroscience research

authors： Acar N,Chardigny JM,Darbois M,Pasquis B,Sébédio JL

更新日期：2003-04-01 00:00:00

abstract：:Considerable evidence suggests that an N-methyl-D-aspartate (NMDA) receptor plays a crucial role in memory and cognitive function. To identify the role of this receptor in higher functions of the brain, we delivered antisense oligonucleotides against an NMDA-NR1 subunit (NR1) to the hippocampus in rats using the HVJ-l...

journal_title：Neuroscience research

authors： Inada K,Ishigooka J,Anzai T,Suzuki E,Miyaoka H,Saji M

更新日期：2003-04-01 00:00:00

abstract：:There is an endocrinological concern that environmental endocrine disrupters (EEDs) may influence sexual differentiation. Bisphenol A (BPA), one of EEDs, is released from polycarbonate plastics, and has been detected in the human umbilical cord. In this study, we examined the effect of BPA on the sexual differentiatio...

journal_title：Neuroscience research

authors： Kubo K,Arai O,Omura M,Watanabe R,Ogata R,Aou S

更新日期：2003-03-01 00:00:00

abstract：:The cyclic nucleotides perform a variety of roles in the formation and remodeling of the neuronal interaction. The membrane microdomain called "raft" has been paid much attention, for this domain contains many signal-transducing molecules including trimeric G proteins and cytoskeletal proteins. The raft domain is reco...

journal_title：Neuroscience research

authors： Noyama K,Maekawa S

更新日期：2003-02-01 00:00:00

abstract：:The distribution of a live attenuated herpes simplex virus (betaH1)-mediated gene delivery into the central nervous system (CNS) was regulated by growth inhibition with ganciclovir (GCV) and the effect of this transgene expression system on the physiologic response was characterized by the acoustic startle response an...

journal_title：Neuroscience research

authors： Fukuda Y,Yamamura J,Uwano T,Nishijo H,Kurokawa M,Fukuda M,Ono T,Shiraki K

更新日期：2003-02-01 00:00:00

abstract：:This experiment tested the effect of haloperidol on the sympathetic and thermogenic effects induced by orexin A. The firing rates of the sympathetic nerves to interscapular brown adipose tissue (IBAT), along with IBAT and colonic temperatures and heart rate were monitored in urethane-anesthetized male Sprague-Dawley r...

journal_title：Neuroscience research

authors： Monda M,Viggiano A,De Luca V

更新日期：2003-01-01 00:00:00

abstract：:Acetylcholinesterase (AChE) activity is increased within and around amyloid plaques, which are present in Alzheimer's disease (AD) patient's brain. In this study, using cultured retinal cells as a neuronal model, we analyzed the effect of the synthetic peptide Abeta(25-35) on the activity of AChE, the degradation enzy...

journal_title：Neuroscience research

authors： Melo JB,Agostinho P,Oliveira CR

更新日期：2003-01-01 00:00:00

abstract：:The recent advent of neuroimaging techniques provides an opportunity to examine brain regions related to a specific memory process such as episodic memory encoding. There is, however, a possibility that areas active during an assumed episodic memory encoding task, compared with a control task, involve not only areas d...

journal_title：Neuroscience research

authors： Fujii T,Okuda J,Tsukiura T,Ohtake H,Suzuki M,Kawashima R,Itoh M,Fukuda H,Yamadori A

更新日期：2002-12-01 00:00:00

abstract：:Swelling of brain cells is one of the physiological responses associated with neuronal activation. To investigate underlying mechanisms, we analyzed interactions between changes in cell volume and synaptic responses in the hippocampal slices from rodents. Swelling within the CA1 area was detected as increases in trans...

journal_title：Neuroscience research

authors： Takagi S,Obata K,Tsubokawa H

更新日期：2002-11-01 00:00:00

abstract：:To clarify a role of neuronal nitric oxide in neurovascular coupling, we performed cerebral blood flow (CBF) and cerebral metabolic rate of glucose (CMR(glc)) measurements with positron emission tomography in somatosensory-stimulated cats using a specific neuronal nitric oxide synthase inhibitor, 7-nitroindazole (7-NI...

journal_title：Neuroscience research

authors： Hayashi T,Katsumi Y,Mukai T,Inoue M,Nagahama Y,Oyanagi C,Yamauchi H,Shibasaki H,Fukuyama H

更新日期：2002-10-01 00:00:00

abstract：:To investigate the effect of abrupt or non-abrupt isolation stress on the classical conditioned histamine release, socially isolated or paired guinea pigs underwent conditioning procedures in which ovalbumin (OA) as an unconditioned stimulus (US) and dimethylsulfide (sulfur smelling) as a conditioned stimulus (CS) wer...

journal_title：Neuroscience research

authors： Irie M,Nagata S,Endo Y

更新日期：2002-09-01 00:00:00

abstract：:The influence of tooth loss on the viability of cholinergic neurons was examined in rats. At 25th postnatal week, rats were divided into the three groups; a control group fed a solid diet, a soft diet group fed a powder diet and a molar crown-less group in which all molar crowns were removed and the powder diet was gi...

journal_title：Neuroscience research

authors： Terasawa H,Hirai T,Ninomiya T,Ikeda Y,Ishijima T,Yajima T,Hamaue N,Nagase Y,Kang Y,Minami M

更新日期：2002-08-01 00:00:00

abstract：:Microglial activation and proliferation occur in nearly all forms of brain injury. The aim of this study was to investigate the influence of glial cell-line derived neurotrophic factor (GDNF) on proliferation and/or survival in a GMIR1 rat microglial cell line, which proliferates in response to granulocyte-macrophage-...

journal_title：Neuroscience research

authors： Salimi K,Moser K,Zassler B,Reindl M,Embacher N,Schermer C,Weis C,Marksteiner J,Sawada M,Humpel C

更新日期：2002-07-01 00:00:00

abstract：:Neuronal nitric oxide synthase (nNOS) mRNA-positive cells were visualized by non-isotopic in situ hybridization histochemistry in the organum vasculosum of the lamina terminalis (OVLT) and the preoptic area (POA) in gonadectomized juvenile female and male rats. In the rostral POA (rPOA) at the level of the anteroventr...

journal_title：Neuroscience research

authors： Ishihara T,Orikasa C,Araki T,Sakuma Y

更新日期：2002-06-01 00:00:00

abstract：:Metabolism of amyloid-beta peptide (Abeta) is closely associated with the pathology and etiology of Alzheimer's disease (AD). Since neprilysin is the only rate-limiting catabolic peptidase proven by reverse genetics to participate in Abeta metabolism in vivo, we performed detailed immunohistochemical analysis of nepri...

journal_title：Neuroscience research

authors： Fukami S,Watanabe K,Iwata N,Haraoka J,Lu B,Gerard NP,Gerard C,Fraser P,Westaway D,St George-Hyslop P,Saido TC

更新日期：2002-05-01 00:00:00

abstract：:While the role of creatine in preventing muscle (peripheral) fatigue for high performance athletes is well understood, its biochemical role in prevention of mental (central) fatigue is not. Creatine is abundant in muscles and the brain and after phosphorylation used as an energy source for adenosine triphosphate synth...

journal_title：Neuroscience research

authors： Watanabe A,Kato N,Kato T

更新日期：2002-04-01 00:00:00

abstract：:We studied developmental changes in respiratory-like C4 activity and respiratory-related neurons in the ventrolateral medulla (VLM) of brainstem-spinal cord preparations from rat fetuses after embryonic day 16 (E16). In addition to respiratory nerve activity, non-respiratory activity was recorded from the C4 ventral r...

journal_title：Neuroscience research

authors： Onimaru H,Homma I

更新日期：2002-03-01 00:00:00

abstract：:Nine healthy male volunteers (mean age of 24) participated in two experimental sessions of random crossover design: a bright light (5000 lux for 5 h from 00:00 to 05:00 h) session and a dim light (10 lux for 5 h from 00:00 to 05:00 h) session. Subsequently participants entered an ultra-short sleep-wake schedule for 26...

journal_title：Neuroscience research

authors： Kubota T,Uchiyama M,Suzuki H,Shibui K,Kim K,Tan X,Tagaya H,Okawa M,Inoue S

更新日期：2002-02-01 00:00:00

abstract：:Excitatory inputs to layer V neurons of the parasubiculum and medial entorhinal cortex were examined in rat brain slices with intracellular and field potential recordings. Single extracellular stimuli to layer V evoked subthreshold excitatory postsynaptic potentials (EPSPs) or a long duration (>100 ms) depolarization ...

journal_title：Neuroscience research

authors： Funahashi M,Matsuo R,Stewart M

更新日期：2002-01-01 00:00:00

abstract：:A time production test was performed in seven normal females and seven females with premenstrual syndrome (PMS). We used a time production test for six time intervals (6, 12, 24, 36, 48, 60 s). Time production tests were performed at 08:00, 14:00 and 20:00 h in the follicular, early luteal and late luteal phases (LLP)...

journal_title：Neuroscience research

authors： Morofushi M,Shinohara K,Kimura F

更新日期：2001-12-01 00:00:00

abstract：:The Madagascan lesser hedgehog tenrec was investigated to get insight into the areal evolution of the hippocampal formation in mammals with poorly differentiated brains. The hippocampal subdivisions were analyzed using cyto- and chemoarchitectural criteria; long associational and commissural connections were demonstra...

journal_title：Neuroscience research

authors： Künzle H,Radtke-Schuller S

更新日期：2001-11-01 00:00:00

abstract：:Effect of serotonin on nitric oxide (NO) production in the ventral nerve cord (VNC) of the earthworm Eisenia fetida was investigated by a bio-imaging and an electrochemical technique. In the bio-imaging, the spatial pattern of NO production in VNC was visualized using an NO-specific fluorescent dye, diaminofluorescein...

journal_title：Neuroscience research

authors： Kitamura Y,Naganoma Y,Horita H,Ogawa H,Oka K

更新日期：2001-10-01 00:00:00

abstract：:Expressions of Cry1 and Cry2 mRNA in the rat pineal gland were examined by Northern blot. The levels of Cry1 and Cry2 transcript had a marked circadian rhythm with peaks at circadian time (CT) 20 in constant darkness. But the amplitude of the Cry1 rhythm was higher than that of the Cry2 rhythm. Furthermore, a signific...

journal_title：Neuroscience research

authors： Nakamura TJ,Shinohara K,Funabashi T,Mitsushima D,Kimura F

更新日期：2001-09-01 00:00:00

abstract：:This study was conducted to ascertain the possible expression of Fos-like immunoreactivity (Fos-LI) in the postsynaptic dorsal column (PSDC) neurons in response to noxious mechanical stimulation of the forepaw glabrous area of normal rats. For this purpose, Fos immunohistochemistry along with Fluoro-Gold (FG) retrogra...

journal_title：Neuroscience research

authors： Day AS,Wen CY,Shieh JY,Sun WZ,Lue JH

更新日期：2001-08-01 00:00:00

abstract：:Steroid hormones substantially influence brain development, reproduction sexual differentiation and emotion. These effects are mediated by steroid hormone receptors and cofactors, which directly regulate gene expression. Deciphering how and where these transcriptional activators occur in a cell provides the groundwork...

journal_title：Neuroscience research

authors： Kawata M,Matsuda K,Nishi M,Ogawa H,Ochiai I

更新日期：2001-07-01 00:00:00

abstract：:In many studies on functional neuroimaging, change in local cerebral blood flow induced by sensory stimulation (evoked LCBF) is used as a marker for change in cortical neuronal activity, although a full description of the relationship between the evoked LCBF and neuronal activity has not been given. The purpose of thi...

journal_title：Neuroscience research

authors： Matsuura T,Kanno I

更新日期：2001-07-01 00:00:00

abstract：:Gene targeting to disrupt gene expression in a temporal and spatial manner in a specific tissue using Cre recombinase-mediated gene inactivation has been proven to be useful to study in vivo gene function. To delete genes specifically in neurons during the late phase of brain development, we have generated transgenic ...

journal_title：Neuroscience research

authors： Hirasawa M,Cho A,Sreenath T,Sauer B,Julien JP,Kulkarni AB

更新日期：2001-06-01 00:00:00

abstract：:Recent technological progress has yielded great amounts of information about the molecular constituents of postsynaptic scaffolds in the dendritic spine. Actin filaments are major cytoskeletal elements in the dendritic spine, and they functionally interact with neurotransmitter receptors via regulatory actin-binding p...

journal_title：Neuroscience research

authors： Shirao T,Sekino Y

更新日期：2001-05-01 00:00:00

abstract：:In the present study, the ability of 5-hydroxytryptamine(2C) (5-HT(2C)) receptors in the hippocampus to enhance locomotor activity in rats was investigated by local infusion. Intraperitoneal injection of the selective 5-HT(2C) antagonist SB 242084 (1 mg/kg) significantly increased rats motor activity, while the effect...

journal_title：Neuroscience research

authors： Takahashi H,Takada Y,Urano T,Takada A

更新日期：2001-05-01 00:00:00

abstract：:The effect of the sodium channel blocking agent tetrodotoxin (TTX) on signal processing in afferent fibres of dorsal roots was tested in Sprague-Dawley rats. TTX applied to the dorsal roots L4-L6 blocked the fast afferent volleys from the sural nerve, which was stimulated electrically with supramaximal strength for A-...

journal_title：Neuroscience research

authors： Steffens H,Hoheisel U,Eek B,Mense S

更新日期：2001-04-01 00:00:00

abstract：:Dynamic properties of horizontal vestibulo-ocular reflex (VOR) and optokinetic response (OKR) were studied in mice. The VOR was examined in the dark (VORD), in the light (VORL) and in the condition in which most of the visual field moves synchronously with the head motion (VORF). A mouse and/or a surrounding screen wi...

journal_title：Neuroscience research

authors： Iwashita M,Kanai R,Funabiki K,Matsuda K,Hirano T

更新日期：2001-03-01 00:00:00

abstract：:Neuropsin is a serine protease cloned from the mouse hippocampus. Since neuropsin is a secreted protein which effectively cleaves fibronectin, it may affect cell adhesion or cell migration by modulating the content and/or chemical characteriscs of fibronectin in extracellular matrix (ECM). In adhesion assays, alpha5B2...

journal_title：Neuroscience research

authors： Tani N,Matsumoto K,Ota I,Yoshida S,Takada Y,Shiosaka S,Matsuura N

更新日期：2001-02-01 00:00:00

abstract：:The facilitatory masseteric muscle response (FMR) elicited by polyurethane foam strip application between the opposing molars during cortically-induced rhythmic jaw movements (CRJMs) was induced earlier than masticatory force onset. The occurrence of this early response of the FMR (e-FMR) could not be explained by a s...

journal_title：Neuroscience research

authors： Komuro A,Masuda Y,Iwata K,Kobayashi M,Kato T,Hidaka O,Morimoto T

更新日期：2001-01-01 00:00:00

abstract：:To examine the role of GABA on prefrontal neuronal activity in the control of behavior, a GABA(A) receptor antagonist, bicuculline methiodite (BMI), was iontophoretically applied to prefrontal neurons while monkeys performed a visual reaction time task. Iontophoretic application of BMI uncovered "task-related" activit...

journal_title：Neuroscience research

authors： Sawaguchi T

更新日期：2001-01-01 00:00:00

abstract：:The purpose of this study was to determine the relationship between the increase in local cerebral blood flow during neuronal activation (evoked LCBF) and the baseline flow level. We measured the hemodynamics in alpha-chloralose-anesthetized rats using laser-Doppler flowmetry during somatosensory stimulation under the...

journal_title：Neuroscience research

authors： Matsuura T,Fujita H,Kashikura K,Kanno I

更新日期：2000-12-01 00:00:00

abstract：:Narcolepsy is a chronic sleep disorder marked by excessive daytime sleepiness, cataplexy, sleep paralysis, and hypnagogic hallucinations. Since the discovery of sleep onset REM periods (SOREMPs) in narcoleptic patients, narcolepsy has often been regarded as a disorder of REM sleep generation: REM sleep intrudes in act...

journal_title：Neuroscience research

authors： Nishino S,Riehl J,Hong J,Kwan M,Reid M,Mignot E

更新日期：2000-12-01 00:00:00

abstract：:The aim of the present study was to test the possibility that the catecholaminergic projectional pathway from the vagus nerve to the medullary visceral zone (MVZ) thence to the paraventricular nucleus of hypothalamus (PVN) was involved in the cytokine-to-brain communication. A triple labeling method in which WGA-HRP r...

journal_title：Neuroscience research

authors： Yang ZJ,Rao ZR,Ju G

更新日期：2000-11-01 00:00:00

abstract：:Forebrain heat shock protein 70 (HSP70) immunohistochemical reactivity was investigated in rats subjected to gamma knife irradiation focusing on the right caudate putamen nucleus. The forebrain sections of all experimental animals were processed with anti-HSP70 antiserum and then by avidin-biotin peroxidase complex im...

journal_title：Neuroscience research

authors： Rao ZR,Ge X,Qiou JY,Yang T,Duan L,Ju G

更新日期：2000-10-01 00:00:00

abstract：:Lateral (L) and medial (M) midbrain astrocytes differ in their ability to support neuritic growth (L, permissive; M, non-permissive) with properties of M glia depending on heparan sulfate (HS). Here we show by atomic force microscopy that the surfaces of formaldehyde-fixed astrocytes differ by conspicuous 250 nm protr...

journal_title：Neuroscience research

authors： Weissmüller G,Garcia-Abreu J,Mascarello Bisch P,Moura Neto V,Cavalcante LA

更新日期：2000-10-01 00:00:00